League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 1638 |
| 2. Daniel Jones, NYG | 1168 | |
| 3. Dwayne Haskins Jr, WAS | 747 | |
| 4. Drew Lock, DEN | 184 | |
| 5. Easton Stick, MIN | 9 | |
| Rushing Yards | Complete List | |
Miles Sanders
|
1. Miles Sanders, PHI | 331 |
| 2. Josh Jacobs, OAK | 268 | |
| 3. David Montgomery, CHI | 139 | |
| 4. Daniel Jones, NYG | 92 | |
| 5. Kyler Murray, ARI | 89 | |
| Receiving Yards | Complete List | |
D.K. Metcalf
|
1. D.K. Metcalf, SEA | 866 |
| 2. Marquise Brown, BAL | 483 | |
| 3. N'Keal Harry, NE | 386 | |
| 4. Parris Campbell, IND | 363 | |
| 5. J.J. Arcega-Whiteside, PHI | 331 | |
League Leaders - Defense
| Tackles | Complete List | |
Justin Hollins
|
1. Justin Hollins, DEN | 34 |
| 2. Rashan Gary, GB | 24 | |
| 3. Darnell Savage Jr, GB | 22 | |
| 4. Jahlani Tavai, DET | 20 | |
| 5. Devin Bush, PIT | 19 | |
| Sacks | Complete List | |
Rashan Gary
|
1. Rashan Gary, GB | 10 |
| 2. L.J. Collier, SEA | 4 | |
| 3. Jaylon Ferguson, BAL | 3 | |
| 4. Quinnen Williams, NYJ | 3 | |
| 5. Justin Hollins, DEN | 3 | |
| Interceptions | Complete List | |
Chris Westry
|
1. Chris Westry, CIN | 5 |
| 2. Justin Hollins, DEN | 3 | |
| 3. Ben Burr-Kirven, SEA | 3 | |
| 4. Cole Holcomb, WAS | 3 | |
| 5. Juan Thornhill, KC | 3 | |