League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 2196 |
| 2. Deshaun Watson, NO | 2121 | |
| 3. Aaron Rodgers, GB | 2033 | |
| 4. Derek Carr, OAK | 1849 | |
| 5. Josh Rosen, WAS | 1848 | |
| Rushing Yards | Complete List | |
Exavier Newton
|
1. Exavier Newton, NYJ | 754 |
| 2. Ezekiel Elliott, DAL | 679 | |
| 3. Saquon Barkley, SEA | 566 | |
| 4. Austin Ekeler, LAC | 555 | |
| 5. Sony Michel, NE | 553 | |
| Receiving Yards | Complete List | |
Jaylen Holmes
|
1. Jaylen Holmes, OAK | 862 |
| 2. Berry Brooks, GB | 756 | |
| 3. D.J. Moore, NO | 745 | |
| 4. Davante Adams, DEN | 722 | |
| 5. Will Fuller V, MIN | 691 | |
League Leaders - Defense
| Tackles | Complete List | |
Deone Bucannon
|
1. Deone Bucannon, ARI | 33 |
| 2. Lorenzo Carter, NO | 31 | |
| 3. Tremaine Edmunds, BUF | 30 | |
| 4. Jamal Adams, NYJ | 30 | |
| 5. Jacorie Medlin, GB | 29 | |
| Sacks | Complete List | |
|
Deone Bucannon
|
1. Deone Bucannon, ARI | 15 |
| 2. Santez Clarke, ATL | 14 | |
| 3. Myles Garrett, CLE | 13 | |
| 4. Von Miller, TEN | 10 | |
| 5. Allen Egnew, CHI | 10 | |
| Interceptions | Complete List | |
Donte Jackson
|
1. Donte Jackson, CAR | 6 |
| 2. Tre'Davious White, BUF | 6 | |
| 3. Desmond King II, LAC | 5 | |
| 4. Jaire Alexander, GB | 5 | |
| 5. Tyrann Mathieu, HOU | 5 | |