League Leaders - Offense
| Passing Yards | Complete List | |
Kendall McLeod
|
1. Kendall McLeod, IND | 1757 |
| 2. Lamar Jackson, BAL | 1459 | |
| 3. Marcus Mariota, TEN | 1401 | |
| 4. Sam Darnold, NYJ | 1397 | |
| 5. Kenan Powell, SEA | 1353 | |
| Rushing Yards | Complete List | |
Tony Pollard
|
1. Tony Pollard, SF | 849 |
| 2. Miles Sanders, NE | 703 | |
| 3. Justin Wright, CLE | 615 | |
| 4. Saquon Barkley, NYJ | 540 | |
| 5. Tarik Cohen, DEN | 507 | |
| Receiving Yards | Complete List | |
Michael Gallup
|
1. Michael Gallup, NYJ | 711 |
| 2. Marquise Brown, LAC | 585 | |
| 3. Cam Baldwin, IND | 560 | |
| 4. Rico Gafford, OAK | 559 | |
| 5. Daryl Stecker, JAX | 557 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 28 |
| 2. Jatavis Brown, MIN | 28 | |
| 3. Shaquem Griffin, MIN | 24 | |
| 4. Derwin James, NE | 24 | |
| 5. Kamu Grugier-Hill, PHI | 23 | |
| Sacks | Complete List | |
Takkarist McKinley
|
1. Takkarist McKinley, NYJ | 13 |
| 2. Nick Bosa, DEN | 12 | |
| 3. Joey Bosa, MIN | 11 | |
| 4. Yannick Ngakoue, JAX | 10 | |
| 5. Montez Sweat, WAS | 9 | |
| Interceptions | Complete List | |
Desmond King II
|
1. Desmond King II, PHI | 4 |
| 2. Tyler McNeil, IND | 4 | |
| 3. Chauncey Gardner-Johnson, SEA | 4 | |
| 4. Juan Thornhill, KC | 4 | |
| 5. Terrell Edmunds, PIT | 3 | |