League Leaders - Offense
| Passing Yards | Complete List | |
Johnny Freeman
|
1. Johnny Freeman, SEA | 4765 |
| 2. Tua Tagovailoa, TEN | 4499 | |
| 3. Justin Herbert, MIA | 4494 | |
| 4. Ty Walden, NYJ | 4443 | |
| 5. Cole Cherry, KC | 4246 | |
| Rushing Yards | Complete List | |
Isaiah Ingram
|
1. Isaiah Ingram, ARI | 1906 |
| 2. Devontae Watson, MIN | 1725 | |
| 3. Cedric Clements, DET | 1723 | |
| 4. Randy Holmes, CIN | 1452 | |
| 5. Christian Peppers, BAL | 1412 | |
| Receiving Yards | Complete List | |
Kasey Overstreet
|
1. Kasey Overstreet, SEA | 2181 |
| 2. Joey Hess, LAC | 1931 | |
| 3. Alex Billups, TB | 1645 | |
| 4. Solomon Thomas, BAL | 1608 | |
| 5. Mecole Hardman, NYG | 1494 | |
League Leaders - Defense
| Tackles | Complete List | |
Taylor Rogers
|
1. Taylor Rogers, SF | 89 |
| 2. Matt Bennett, NYJ | 86 | |
| 3. Willie Gay, KC | 83 | |
| 4. Jon Milloy, GB | 82 | |
| 5. LaJarvis Ridley, WAS | 81 | |
| Sacks | Complete List | |
Joe Bennett
|
1. Joe Bennett, ARI | 21 |
| 2. Danielle Hunter, DET | 20 | |
| 3. Landry Betts, LAC | 18 | |
| 4. DeMarco Ellison, BAL | 18 | |
| 5. Willie Stapleton, CIN | 14 | |
| Interceptions | Complete List | |
Treyvon Kendricks
|
1. Treyvon Kendricks, MIN | 8 |
| 2. Malachi Gaither, LAC | 8 | |
| 3. Connor Rowe, NYG | 8 | |
| 4. Diondre Brown, MIA | 7 | |
| 5. Stevie James, JAX | 7 | |