League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, BUF | 4579 |
| 2. Eli Pope, ATL | 4560 | |
| 3. Billy Overbay, MIN | 4531 | |
| 4. Kyler Murray, CAR | 4222 | |
| 5. Kirk Cousins, PIT | 4195 | |
| Rushing Yards | Complete List | |
Saquon Barkley
|
1. Saquon Barkley, NE | 2369 |
| 2. Derrius Guice, WAS | 2107 | |
| 3. Todd Gurley II, LAR | 1839 | |
| 4. Bryce Love, TEN | 1830 | |
| 5. Tevin Coleman, SF | 1471 | |
| Receiving Yards | Complete List | |
Scott Miller
|
1. Scott Miller, MIN | 1773 |
| 2. Curtis Samuel, CAR | 1724 | |
| 3. Marquise Brown, BAL | 1709 | |
| 4. Michael Gallup, NYJ | 1564 | |
| 5. Amari Cooper, DAL | 1549 | |
League Leaders - Defense
| Tackles | Complete List | |
Deion Jones
|
1. Deion Jones, ATL | 79 |
| 2. Haason Reddick, CAR | 69 | |
| 3. Jerome Baker, WAS | 69 | |
| 4. Devin White, TB | 68 | |
| 5. Zach Cunningham, HOU | 66 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, MIN | 43 |
| 2. Aaron Donald, LAR | 38 | |
| 3. DeMarcus Lawrence, DAL | 35 | |
| 4. Fletcher Cox, PHI | 33 | |
| 5. Takkarist McKinley, NYJ | 32 | |
| Interceptions | Complete List | |
Stephon Gilmore
|
1. Stephon Gilmore, NE | 14 |
| 2. Devin McCourty, ARI | 11 | |
| 3. Adoree' Jackson, TEN | 10 | |
| 4. William Jackson, OAK | 10 | |
| 5. Marshon Lattimore, NO | 10 | |