League Leaders - Offense
| Passing Yards | Complete List | |
Turner DeCicco
|
1. Turner DeCicco, TEN | 4272 |
| 2. Glenn Moorman, LAC | 4143 | |
| 3. Marcus Mariota, CIN | 4121 | |
| 4. Andrew Luck, SEA | 3804 | |
| 5. Patrick Mahomes, KC | 3780 | |
| Rushing Yards | Complete List | |
Nyheim Hines
|
1. Nyheim Hines, MIN | 1426 |
| 2. Morgan Stevens, CAR | 1117 | |
| 3. Steven Love, MIA | 982 | |
| 4. Leonard Fournette, WAS | 958 | |
| 5. Saquon Barkley, SEA | 940 | |
| Receiving Yards | Complete List | |
Riley Leake
|
1. Riley Leake, CIN | 1721 |
| 2. Berry Brooks, GB | 1571 | |
| 3. Isaic Rawls, GB | 1498 | |
| 4. John Ross, LAC | 1490 | |
| 5. Rashaun Hubbard, SEA | 1465 | |
League Leaders - Defense
| Tackles | Complete List | |
Marshall Frost
|
1. Marshall Frost, TB | 64 |
| 2. Raekwon McMillan, ATL | 60 | |
| 3. Howard Harper, ATL | 60 | |
| 4. Kevin Carroll, OAK | 58 | |
| 5. Gareef McBride, WAS | 57 | |
| Sacks | Complete List | |
DeSean Watts
|
1. DeSean Watts, BUF | 24 |
| 2. Marcus Davenport, HOU | 22 | |
| 3. Rashaun Verdon, MIA | 21 | |
| 4. Joey Bosa, LAC | 21 | |
| 5. Ryan Pino, LAC | 20 | |
| Interceptions | Complete List | |
Anthony Byrum
|
1. Anthony Byrum, WAS | 10 |
| 2. Jaire Alexander, GB | 10 | |
| 3. Donte Jackson, TEN | 9 | |
| 4. Adoree' Jackson, KC | 8 | |
| 5. William Jackson, SF | 7 | |