League Leaders - Offense
| Passing Yards | Complete List | |
Johnny Freeman
|
1. Johnny Freeman, SEA | 5018 |
| 2. Tua Tagovailoa, TEN | 4769 | |
| 3. Justin Herbert, MIA | 4695 | |
| 4. Ty Walden, NYJ | 4443 | |
| 5. Dwayne Haskins Jr, MIN | 4306 | |
| Rushing Yards | Complete List | |
Isaiah Ingram
|
1. Isaiah Ingram, ARI | 1906 |
| 2. Devontae Watson, MIN | 1817 | |
| 3. Cedric Clements, DET | 1723 | |
| 4. Christian Peppers, BAL | 1586 | |
| 5. Randy Holmes, CIN | 1452 | |
| Receiving Yards | Complete List | |
Kasey Overstreet
|
1. Kasey Overstreet, SEA | 2280 |
| 2. Joey Hess, LAC | 2038 | |
| 3. Alex Billups, TB | 1810 | |
| 4. Solomon Thomas, BAL | 1643 | |
| 5. Mecole Hardman, NYG | 1618 | |
League Leaders - Defense
| Tackles | Complete List | |
Taylor Rogers
|
1. Taylor Rogers, SF | 89 |
| 2. Matt Bennett, NYJ | 86 | |
| 3. Willie Gay, KC | 83 | |
| 4. Jacob Phillips, NE | 82 | |
| 5. Jon Milloy, GB | 82 | |
| Sacks | Complete List | |
Joe Bennett
|
1. Joe Bennett, ARI | 21 |
| 2. Danielle Hunter, DET | 20 | |
| 3. Landry Betts, LAC | 18 | |
| 4. DeMarco Ellison, BAL | 18 | |
| 5. Kaleb Selvie, LAC | 15 | |
| Interceptions | Complete List | |
Connor Rowe
|
1. Connor Rowe, NYG | 10 |
| 2. Treyvon Kendricks, MIN | 9 | |
| 3. Minkah Fitzpatrick, MIN | 8 | |
| 4. Malachi Gaither, LAC | 8 | |
| 5. Trayvon Van Buren, LAC | 7 | |