League Leaders - Offense
| Passing Yards | Complete List | |
Deshaun Watson
|
1. Deshaun Watson, NO | 1433 |
| 2. Patrick Mahomes, KC | 1390 | |
| 3. Malcolm Starkey, GB | 1377 | |
| 4. Evan Leach, HOU | 1309 | |
| 5. Josh Allen, BUF | 1301 | |
| Rushing Yards | Complete List | |
Khrystian Milton
|
1. Khrystian Milton, MIN | 604 |
| 2. Eric Ajirotutu, PIT | 436 | |
| 3. Taqwaun King, CLE | 423 | |
| 4. Rashaad Poyer, NO | 422 | |
| 5. Ronald Jones II, TB | 389 | |
| Receiving Yards | Complete List | |
Isaic Rawls
|
1. Isaic Rawls, GB | 716 |
| 2. D.J. Chark Jr, JAX | 602 | |
| 3. Kyran Long, IND | 582 | |
| 4. Jaylen Holmes, OAK | 574 | |
| 5. Breshad Perriman, KC | 499 | |
League Leaders - Defense
| Tackles | Complete List | |
Anthony Barr
|
1. Anthony Barr, MIN | 25 |
| 2. Marshall Frost, TB | 23 | |
| 3. Lamar Calico, ARI | 23 | |
| 4. Jordan Higgins, PIT | 23 | |
| 5. Deion Jones, BAL | 23 | |
| Sacks | Complete List | |
Adrian Torrence
|
1. Adrian Torrence, NO | 14 |
| 2. DeSean Watts, BUF | 10 | |
| 3. Yannick Ngakoue, KC | 10 | |
| 4. Joey Bosa, LAC | 9 | |
| 5. Roshawn Griffith, MIN | 8 | |
| Interceptions | Complete List | |
Akeem Spriggs
|
1. Akeem Spriggs, NE | 7 |
| 2. Matt Bowers, SEA | 4 | |
| 3. Tremaine Edmunds, BUF | 4 | |
| 4. Jourdan Lewis, TEN | 4 | |
| 5. Tavares Creer, OAK | 3 | |