League Leaders - Offense
| Passing Yards | Complete List | |
Joe Burrow
|
1. Joe Burrow, CIN | 2798 |
| 2. Johnny Freeman, SEA | 2678 | |
| 3. Tyler McClellan, CLE | 2550 | |
| 4. Justin Herbert, MIA | 2421 | |
| 5. Cameron Pritchard, NE | 2407 | |
| Rushing Yards | Complete List | |
Jaden Rossum
|
1. Jaden Rossum, ARI | 1306 |
| 2. Ezekiel Elliott, LAC | 1175 | |
| 3. Jonathan Taylor, IND | 1105 | |
| 4. Randy Holmes, CIN | 1056 | |
| 5. Phillip Pitts, NO | 1017 | |
| Receiving Yards | Complete List | |
Darius Slayton
|
1. Darius Slayton, NE | 1178 |
| 2. Kasey Overstreet, SEA | 1169 | |
| 3. Frank Baskerville, TEN | 1149 | |
| 4. Cordell McCray, MIA | 1073 | |
| 5. Anfernee Benson, CIN | 1035 | |
League Leaders - Defense
| Tackles | Complete List | |
Roquan Smith
|
1. Roquan Smith, CHI | 48 |
| 2. Lonnie Connor, GB | 41 | |
| 3. Tyler McKnight, BAL | 38 | |
| 4. Ross Bonds, DET | 37 | |
| 5. Tavaris Northrup, CIN | 37 | |
| Sacks | Complete List | |
Deacon Turner
|
1. Deacon Turner, CIN | 16 |
| 2. Donovan Beasley, NE | 15 | |
| 3. Danielle Hunter, DET | 11 | |
| 4. Landry Betts, LAC | 10 | |
| 5. DeMarcus Mason, PHI | 8 | |
| Interceptions | Complete List | |
Jaylon Johnson
|
1. Jaylon Johnson, CHI | 8 |
| 2. Rafael Kelley, LAC | 7 | |
| 3. Andrew Hambrick, BAL | 7 | |
| 4. Desmond King II, LAC | 6 | |
| 5. Juan Thornhill, KC | 6 | |