League Leaders - Offense
| Passing Yards | Complete List | |
Bryce Heppner
|
1. Bryce Heppner, NYG | 3277 |
| 2. Jimmy Garoppolo, SF | 3230 | |
| 3. Aaron Rodgers, GB | 3168 | |
| 4. Russell Wilson, SEA | 3131 | |
| 5. Derek Carr, OAK | 3090 | |
| Rushing Yards | Complete List | |
Le'Veon Bell
|
1. Le'Veon Bell, TEN | 1379 |
| 2. Alvin Kamara, GB | 1161 | |
| 3. Todd Gurley II, LAR | 1109 | |
| 4. Ezekiel Elliott, DAL | 997 | |
| 5. Leonard Fournette, JAX | 883 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, KC | 1458 |
| 2. John Ross, SEA | 1380 | |
| 3. Ja'Darius Figurs, ATL | 1310 | |
| 4. Isaic Rawls, BUF | 1296 | |
| 5. Berry Brooks, GB | 1157 | |
League Leaders - Defense
| Tackles | Complete List | |
Parker Hudson
|
1. Parker Hudson, IND | 42 |
| 2. Jaquiski Tartt, MIN | 42 | |
| 3. Demario Davis, MIN | 41 | |
| 4. Adrian Amos Jr, CHI | 40 | |
| 5. Deion Jones, ATL | 39 | |
| Sacks | Complete List | |
Takkarist McKinley
|
1. Takkarist McKinley, ATL | 25 |
| 2. DeSean Watts, GB | 16 | |
| 3. Myles Garrett, CLE | 14 | |
| 4. Aaron Donald, PIT | 13 | |
| 5. Denard Roberts, NO | 13 | |
| Interceptions | Complete List | |
Akeem Spriggs
|
1. Akeem Spriggs, NE | 8 |
| 2. Adoree' Jackson, PIT | 7 | |
| 3. Xavier Rhodes, WAS | 7 | |
| 4. Deion Jones, ATL | 6 | |
| 5. Earl Thomas III, SEA | 6 | |