League Leaders - Offense
| Passing Yards | Complete List | |
Justin Herbert
|
1. Justin Herbert, LAC | 3356 |
| 2. Tua Tagovailoa, MIA | 3280 | |
| 3. Joe Burrow, CIN | 3279 | |
| 4. Jacob Eason, IND | 2380 | |
| 5. Cole McDonald, ATL | 789 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, IND | 1442 |
| 2. Clyde Edwards-Helaire, KC | 1106 | |
| 3. Cam Akers, LAR | 849 | |
| 4. Karan Higdon, HOU | 838 | |
| 5. J.K. Dobbins, BAL | 591 | |
| Receiving Yards | Complete List | |
Henry Ruggs III
|
1. Henry Ruggs III, LV | 1322 |
| 2. Bronson Rechsteiner, WAS | 1238 | |
| 3. Denzel Mims, NYJ | 1121 | |
| 4. Devin Duvernay, BAL | 1048 | |
| 5. Quez Watkins, PHI | 913 | |
League Leaders - Defense
| Tackles | Complete List | |
Isaiah Simmons
|
1. Isaiah Simmons, ARI | 40 |
| 2. Davion Taylor, PHI | 36 | |
| 3. Patrick Queen, BAL | 36 | |
| 4. Akeem Davis-Gaither, CIN | 35 | |
| 5. Xavier McKinney, NYG | 34 | |
| Sacks | Complete List | |
Jadeveon Clowney
|
1. Jadeveon Clowney, MIA | 8 |
| 2. Darrell Taylor, SEA | 4 | |
| 3. Javon Kinlaw, SF | 3 | |
| 4. Chase Young, WAS | 3 | |
| 5. Carter Coughlin, NYG | 3 | |
| Interceptions | Complete List | |
Darnay Holmes
|
1. Darnay Holmes, NYG | 8 |
| 2. Isaiah Simmons, ARI | 8 | |
| 3. Jeremy Chinn, CAR | 6 | |
| 4. Xavier McKinney, NYG | 6 | |
| 5. Kenny Robinson Jr, CAR | 6 | |